PUP.Optional.NotChromeRun is a generic detection for values under the registry key, HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Run, that point to a file called Chrome.exe. However, the said file is not the actual Chrome browser executable. In most cases, this is a Chromium build that is planted by malware or PUPs.
PUP.Optional.NotChromeRun is a “removal only” detection and does not offer protection.
Malwarebytes can detect and remove PUP.Optional.NotChromeRun without further user interaction.
When PUP.Optional.NotChromeRun is detected on your computer, Malwarebytes for Windows does not know if it was authorized. Optimization software, malware, and potentially unwanted programs (PUPs) are known to make these types of changes, hence they are regarded as potentially unwanted.
To have Malwarebytes for Windows ignore PUP.Optional.NotChromeRun, you must add PUP.Optional.NotChromeRun as an exclusion.
When PUP.Optional.NotChromeRun is excluded, Malwarebytes for Windows does not detect PUP.Optional.NotChromeRun during scans or real-time protection.